OncoMatch/Clinical Trials/NCT06215950
A Clinical Research About CD70-targeted CAR-T in the Treatment of CD70-positive Advanced/Metastatic Gynecologic Cancer
Is NCT06215950 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies multiple treatments including CD70 CAR-T cells and CD70 CAR-T cells for ovarian cancer.
Treatment: CD70 CAR-T cells · CD70 CAR-T cells — This is a single-center, double-arm, open-label study. this study plans to evaluate the safety and efficacy of CD70-targeting CAR-T cells in the treatment of CD70-positive advanced/metastatic Gynecologic Cancer, and obtain recommended doses and infusion patterns.
Check if I qualifyExtracted eligibility criteria
Cancer type
Ovarian Cancer
Cervical Cancer
Tumor Agnostic
Biomarker criteria
Required: CD70 overexpression (IHC 3+)
CD70 positive tumor expression (CD70 positive tumor confirmed by histology or pathology (IHC 3+))
Disease stage
Metastatic disease required
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Must have received: standard treatment
Failure or intolerance after standard treatment (disease progression or intolerance such as surgery, chemotherapy, radiotherapy, targeted therapy, etc.), and currently no effective treatment
Cannot have received: anti-CD70 therapy
Received anti-CD70 drug therapy before screening
Lab requirements
Blood counts
neutral granules >1.0×109/l, platelet >75×109/l, hemoglobin >80g/l
Kidney function
serum creatinine ≤2.0×uln
Liver function
alt and ast ≤2.0×uln (patients with liver tumor infiltration can be relaxed to ≤3.0×uln); total bilirubin ≤2.0×uln (gilbert syndrome or liver tumor infiltration can be relaxed to ≤3.0×uln)
Cardiac function
echocardiography indicated cardiac ejection fraction ≥50%, and no obvious abnormality was found in electrocardiogram
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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