OncoMatch/Clinical Trials/NCT06205316
SBRT Versus Hypofractionated Radiotherapy for Biochemically Recurrent or Oligometastatic Prostate Adenocarcinoma
Is NCT06205316 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies Antiandrogen Therapy for biochemically recurrent prostate carcinoma.
Treatment: Antiandrogen Therapy — This phase III trial tests the side effects of stereotactic body radiation therapy (SBRT) compared to hypofractionated radiotherapy for treating patients with prostate adenocarcinoma that has come back after a period of improvement (recurrent) or that has spread from where it first started (primary site) to a limited number of sites (oligometastatic). SBRT is a type of external radiation therapy that uses special equipment to position a patient and precisely deliver radiation to tumors in the body (except the brain). The total dose of radiation is divided into smaller doses given over several days. This type of radiation therapy helps spare normal tissue. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumors cells and have fewer side effects. SBRT may work just as well as hypofractionated radiation therapy at treating patients with biochemically recurrent or oligometastatic prostate cancer, but with a shorter treatment time and possibly fewer side effects.
Check if I qualifyExtracted eligibility criteria
Cancer type
Prostate Cancer
Disease stage
Required: Stage IIB, IIC, III, IV
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: pelvic radiation
Previous pelvic radiation
Cannot have received: androgen deprivation therapy
Exception: only if PSA ≥ 0.1 ng/mL
Prior androgen deprivation therapy for prostate cancer and PSA ≥ 0.1 ng/mL
Cannot have received: systemic chemotherapy
Prior systemic chemotherapy for prostate cancer
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Mayo Clinic in Arizona · Scottsdale, Arizona
- Mayo Clinic Health System in Albert Lea · Albert Lea, Minnesota
- Mayo Clinic Health System - Mankato · Mankato, Minnesota
- Mayo Clinic in Rochester · Rochester, Minnesota
- Mayo Clinic Health System-Eau Claire Clinic · Eau Claire, Wisconsin
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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