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OncoMatch/Clinical Trials/NCT06168786

Cadonilimab Combined With Fruquintinib and SBRT as Athird-line and Posterior Line Treatment in Patients With MSS CRC

Is NCT06168786 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Fruquintinib and Cadonilimab for colorectal cancer.

Phase 2RecruitingHuazhong University of Science and TechnologyNCT06168786Data as of May 2026

Treatment: Fruquintinib · Cadonilimab — A Phase II Study to Assess the Efficacy and Safety of Cadonilimab Combined With Fruquintinib and SBRT as A third-line and Posterior Line Treatment in Patients With MSS Colorectal Cancer

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Extracted eligibility criteria

Cancer type

Colorectal Cancer

Disease stage

Required: Stage IV

Metastatic disease required

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

Min 2 prior lines

Must have received: cytotoxic chemotherapy (fluorouracil, oxaliplatin, irinotecan, bevacizumab, cetuximab)

At least two or more standard systemic therapies prior treatment (based on Fu, oxaliplatin, irinotecan, bevacizumab and cetuximab) of cytotoxic chemotherapy, treatment failure or intolerable toxicities

Cannot have received: anti-PD-1 therapy

Patients have received anti-PD-1 / PD-L1 or anti-CTLA-4 immunotherapy or other immunoexperimental drugs

Cannot have received: anti-PD-L1 therapy

Patients have received anti-PD-1 / PD-L1 or anti-CTLA-4 immunotherapy or other immunoexperimental drugs

Cannot have received: anti-CTLA-4 therapy

Patients have received anti-PD-1 / PD-L1 or anti-CTLA-4 immunotherapy or other immunoexperimental drugs

Lab requirements

Kidney function

creatinine < ULN

Liver function

AST, ALT and alkaline phosphatase ≤ 2.5 times the upper limit of normal (ULN), Serum bilirubin ≤ 1.5 x ULN

AST, ALT and alkaline phosphatase ≤ 2.5 times the upper limit of normal (ULN)，Serum bilirubin ≤ 1.5 x ULN，creatinine<ULN

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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