OncoMatch/Clinical Trials/NCT06167291
Phase II Randomized-registry Embedded Study of Lymphoscintigraphy for Oropharyngeal Neoplasms to Enable Risk-adapted Nodal Guidance for Robotic Surgery and/or Radiotherapy (LONE-RANGR2)
Is NCT06167291 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies non-drug interventions for oropharyngeal neoplasms.
To test a new radiation treatment design based on where your cancer is located. Most participants with oropharyngeal cancer are treated with radiation to both sides of the neck. However, for participants with oropharyngeal cancer on one side of the neck, receiving radiation to both sides of the neck may result in increased side effects and radiation exposure. This study is testing the safety and effectiveness of an approach that involves radiation to only one side of the neck in an effort to reduce the overall amount of radiation given and decrease the amount of side effects you may experience.
Check if I qualifyExtracted eligibility criteria
Biomarker criteria
Required: CDKN2A overexpression (p16+)
p16+
Required: HPV positive (HPV+)
HPV+
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: chemotherapy
Chemotherapy or surgery (for the present tumor), prior to inclusion
Cannot have received: surgery
Chemotherapy or surgery (for the present tumor), prior to inclusion
Cannot have received: radiation therapy
Exception: except for cutaneous lesions that would not lead to overlap with definitive bilateral neck irradiation
Previous radiation treatment in the head and neck region, for any reason, except for cutaneous lesions that would not lead to overlap with definitive bilateral neck irradiation
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- MD Anderson Cancer Center · Houston, Texas
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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