OncoMatch/Clinical Trials/NCT06162650
Total Neoadjuvant Therapy in Rectal Cancer
Is NCT06162650 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies mFOLFOX6 for rectal cancer.
Treatment: mFOLFOX6 — In this phase 2 study, the efficacy of total neoadjuvant therapy in Taiwanese patients with rectal cancer will be investigated. Patients with stage II or III middle/low rectal cancer will be prospective enrolled. The total neoadjuvant therapy with the short-course radiotherapy (5×5 Gy over a maximum of 8 days) followed by chemotherapy with mFOLFOX6 for 9 cycles will be administered. The primary endpoint is the complete response (CR) rate which will take into account the patients with clinical and pathological complete response.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Colorectal Cancer
Disease stage
Required: Stage II, III
Performance status
ECOG 0–1(Restricted strenuous activity)
Demographics
Prior therapy
Cannot have received: chemotherapy
No prior chemotherapy, radiotherapy or surgery for rectal cancer
Cannot have received: radiotherapy
No prior chemotherapy, radiotherapy or surgery for rectal cancer
Cannot have received: surgery
No prior chemotherapy, radiotherapy or surgery for rectal cancer
Cannot have received: pelvic radiotherapy
Patients who have received prior pelvic radiotherapy
Lab requirements
Blood counts
anc ≥1,500/μl; hb ≥8.0 gm/dl; platelet 100,000/mm3
Kidney function
creatinine ≤1.5x upper normal limit
Liver function
total bilirubin ≤1.5x upper normal limit; ast ≤3x upper normal limit; alt ≤3x upper normal limit
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT06162650 currently recruiting?
Yes, this trial is currently recruiting patients.
Can patients have received prior systemic therapy?
No. This trial requires treatment-naive patients — prior systemic therapy is an exclusion criterion.
What disease stage is eligible?
Stage II or III is required.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages