OncoMatch/Clinical Trials/NCT06147570
A Study of HS-10365 in Patients With Advanced or Metastatic RET Fusion-Positive Non-Small Cell Lung Cancer
Is NCT06147570 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies HS-10365 capsules for nonsmall cell lung cancer.
Treatment: HS-10365 capsules — HS-10365 is a small molecular, oral potent, selective RET inhibitor. The purpose of this study is to investigate the efficacy and safety of HS-10365 in Chinese advanced RET fusion-positive non-small cell lung cancer patients without any systemic therapy.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Non-Small Cell Lung Carcinoma
Biomarker criteria
Required: RET fusion
Disease stage
Required: Stage IIIB, IIIC, IV
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: selective RET inhibitor
Previous or current treatment with selective RET inhibitors
Cannot have received: multi-kinase inhibitor of RET
Previous or current treatment with ... multi-kinase Inhibitor of RET
Cannot have received: systemic therapy
Exception: adjuvant/neoadjuvant therapy completed at least 6 months prior to relapse
Prior systemic therapy for metastatic disease. Treatment (including chemotherapy or immunotherapy) in the adjuvant/neoadjuvant setting is permitted if it was completed at least 6 months prior to relapse.
Lab requirements
Blood counts
adequate bone marrow reserve required
Inadequate bone marrow reserve or serious organ dysfunction [excluded].
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT06147570 currently recruiting?
Yes, this trial is currently recruiting patients.
Can patients have received prior systemic therapy?
No. This trial requires treatment-naive patients — prior systemic therapy is an exclusion criterion.
Does this trial require RET?
Yes, RET fusion is a required biomarker for enrollment.
What disease stage is eligible?
Stage IIIB or IIIC or IV is required.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages