OncoMatch/Clinical Trials/NCT06139926
Clinical Study of Dexmedetomidine Administered Intranasally to Relieve Perioperative Anxiety and Depression in Patients With Colorectal Tumors
Is NCT06139926 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies Dexmedetomidine administered intranasally for colorectal cancer.
Treatment: Dexmedetomidine administered intranasally — Currently, domestic and international research on dexmedetomidine as well as anxiety and depression is more focused on basic research. In terms of clinical research, dexmedetomidine is more often used in pediatrics, short surgeries, intensive care units, etc., for sedation and analgesia; while less research has been done for the relief of anxiety and depression. At present, on the one hand, the number of oncology patients is on the rise both at home and abroad, and on the other hand, anxiety and depression account for an increasing proportion of healthcare in the world. Tumor patients, as a high prevalence group of anxiety and depression, their prognosis and regression are also more complicated. Therefore, exploring the role of intranasal administration of dexmedetomidine in relieving perioperative anxiety and depression in oncology patients has a very strong practical basis and clinical significance.
Check if I qualifyExtracted eligibility criteria
Cancer type
Colorectal Cancer
Performance status
ASA 2–3
Prior therapy
Lab requirements
Kidney function
No serious abnormalities of kidney function
Liver function
No serious abnormalities of liver function
Cardiac function
No second or third degree atrioventricular block, severe sinus bradycardia (<50 beats/min), sick sinus node syndrome, congenital heart disease, or other cardiac arrhythmias that severely affect hemodynamic stability
Serious abnormalities of liver or kidney function. Second or third degree atrioventricular block, severe sinus bradycardia (<50 beats/min), sick sinus node syndrome, congenital heart disease, and other cardiac arrhythmias that severely affect hemodynamic stability
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