OncoMatch/Clinical Trials/NCT06121843
A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma
Is NCT06121843 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies multiple treatments for multiple myeloma.
Treatment: BMS-986393 · Alnuctamab · Mezigdomide · Iberdomide · Elranatamab — The purpose of this study is to establish a safe and tolerable dose of arlocabtagene autoleucel (BMS-986393) in combinations with alnuctamab, mezigdomide, iberdomide, and elranatamab in participants with relapsed and/or refractory multiple myeloma (RRMM).
Check if I qualifyExtracted eligibility criteria
Cancer type
Multiple Myeloma
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: anti-myeloma treatment
treated with at least 3 (Part 1) or at least 1 but not greater than 3 prior anti-myeloma treatment regimens (Part 2)
Cannot have received: (alnuctamab)
Exception: Arm A only
Prior treatment with alnuctamab (Arm A)
Cannot have received: (mezigdomide)
Exception: Arm B only
Prior treatment with mezigdomide (Arm B)
Cannot have received: (iberdomide)
Exception: Arm C only
Prior treatment with iberdomide (Arm C)
Cannot have received: (elranatamab)
Exception: Arm D only
Prior treatment with elranatamab (Arm D)
Cannot have received: BCMA-targeting therapy
Exception: Part 2 Arms A and D only
Prior treatment with BCMA-targeting therapy (Part 2 Arms A and D)
Cannot have received: GPRC5D-targeting therapy
Prior treatment with GPRC5D-targeting therapies
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- University of Alabama at Birmingham · Birmingham, Alabama
- Mayo Clinic in Arizona - Phoenix · Phoenix, Arizona
- City of Hope Comprehensive Cancer Center · Duarte, California
- Mayo Clinic in Florida · Jacksonville, Florida
- Northside Hospital · Atlanta, Georgia
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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