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OncoMatch/Clinical Trials/NCT06121843

A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma

Is NCT06121843 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies multiple treatments for multiple myeloma.

Phase 1RecruitingJuno Therapeutics, Inc., a Bristol-Myers Squibb CompanyNCT06121843Data as of May 2026

Treatment: BMS-986393 · Alnuctamab · Mezigdomide · Iberdomide · ElranatamabThe purpose of this study is to establish a safe and tolerable dose of arlocabtagene autoleucel (BMS-986393) in combinations with alnuctamab, mezigdomide, iberdomide, and elranatamab in participants with relapsed and/or refractory multiple myeloma (RRMM).

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Extracted eligibility criteria

Cancer type

Multiple Myeloma

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

Max 3 prior lines
Min 3 prior lines

Must have received: anti-myeloma treatment

treated with at least 3 (Part 1) or at least 1 but not greater than 3 prior anti-myeloma treatment regimens (Part 2)

Cannot have received: (alnuctamab)

Exception: Arm A only

Prior treatment with alnuctamab (Arm A)

Cannot have received: (mezigdomide)

Exception: Arm B only

Prior treatment with mezigdomide (Arm B)

Cannot have received: (iberdomide)

Exception: Arm C only

Prior treatment with iberdomide (Arm C)

Cannot have received: (elranatamab)

Exception: Arm D only

Prior treatment with elranatamab (Arm D)

Cannot have received: BCMA-targeting therapy

Exception: Part 2 Arms A and D only

Prior treatment with BCMA-targeting therapy (Part 2 Arms A and D)

Cannot have received: GPRC5D-targeting therapy

Prior treatment with GPRC5D-targeting therapies

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • University of Alabama at Birmingham · Birmingham, Alabama
  • Mayo Clinic in Arizona - Phoenix · Phoenix, Arizona
  • City of Hope Comprehensive Cancer Center · Duarte, California
  • Mayo Clinic in Florida · Jacksonville, Florida
  • Northside Hospital · Atlanta, Georgia

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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