OncoMatch/Clinical Trials/NCT06112990
Creatine Supplementation and Resistance Training to Preserve Muscle Mass and Attenuate Cancer Progression
Is NCT06112990 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies non-drug interventions for metastatic prostate cancer.
The goal of this clinical trial is to test the use of creatine monohydrate supplementation with resistance training to preserve muscle mass and help lessen prostate cancer progression. The main question it aims to answer is if this treatment will help maintain muscle mass to help in reducing fatigue and improving physical function, independence, and quality of life. Participants will be asked to participate in a 52-week exercise intervention consisting of a twice weekly telehealth resistance training program.
Check if I qualifyExtracted eligibility criteria
Cancer type
Prostate Cancer
Disease stage
Metastatic disease required
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Must have received: androgen deprivation therapy (surgical castration, GnRH agonist, GnRH antagonist, androgen receptor pathway inhibitor, abiraterone, enzalutamide, apalutamide, darolutamide) — current
Currently treated with surgical castration or medical castration with Gonadotropin-releasing hormone (GnRH) agonists/antagonists, and/or an androgen receptor pathway inhibitor (ARPI)) aka novel hormone therapy (e.g., abiraterone, enzalutamide, apalutamide, darolutamide). Must have started the current regimen at least 12 weeks prior to enrollment.
Cannot have received: cytotoxic chemotherapy
Treatment with cytotoxic chemotherapy within 12 weeks prior to enrollment.
Lab requirements
Kidney function
Estimated Glomerular Filtration Rate (eGFR) ≥ 30 ml/min/1.73m2
Estimated Glomerular Filtration Rate (eGFR) < 30 ml/min/1.73m2 [excluded].
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Huntsman Cancer Institute · Salt Lake City, Utah
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