OncoMatch/Clinical Trials/NCT06107920
Neoadjuvant Chemotherapy for Obstructive Colon cancER First Treated by cOlostomy
Is NCT06107920 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies Neoadjuvant chemotherapy for colon cancer.
Treatment: Neoadjuvant chemotherapy — The aim of this study is to determine whether chemotherapy prior to tumor removal (neoadjuvant chemotherapy), in patients undergoing treatment for colon cancer in occlusion (CCO), would improve the rate of patients able to benefit from "optimal" treatment, i.e. complete treatment (including all neoadjuvant and adjuvant chemotherapy cures). This new strategy, which would combine chemotherapy before surgery and possibly post-operatively (depending on tumor analysis), could improve the prognosis of occluded colon cancers by treating circulating micrometastases and/or inducing a reduction in tumor size, thereby increasing the rate of complete resection.
Check if I qualifyExtracted eligibility criteria
Cancer type
Colorectal Cancer
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: chemotherapy
No prior chemotherapy
Cannot have received: abdominal or pelvic irradiation
No prior chemotherapy or abdominal or pelvic irradiation
Cannot have received: radiation therapy
Patient having received radiation therapy prior to surgery
Lab requirements
Blood counts
White blood cell count ≥ 3.109 /L with Neutrophils ≥ 1.5.109 / L, Platelet count ≥ 100.109 / L, Hemoglobin ≥ 9 g/dL (5.6 mmol/L)
Kidney function
Serum creatinine ≤ 1.5 x ULN (performed 10-15 days prior to randomization)
Liver function
Total bilirubin ≤ 1.5 x ULN, ASAT and ALAT ≤ 2.5 x ULN, Alkaline phosphatase ≤ 1.5 x ULN
Laboratory data including : White blood cell count ≥ 3.109 /L with Neutrophils ≥ 1,5.109 / L, Platelet count ≥ 100.109 / L, Hemoglobin ≥ 9 g/dL (5,6 mmol/L), Total bilirubin ≤ 1,5 x ULN (upper limit of normal), ASAT and ALAT ≤ 2,5 x ULN, Alkaline phosphatase ≤ 1,5 x ULN, Serum creatinine ≤ 1,5 x ULN (performed 10-15 days prior to randomization).
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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