OncoMatch

OncoMatch/Clinical Trials/NCT06106672

Evaluate the Safety, Tolerability, Pharmacodynamics and Efficacy of CNP-106 in Subjects With Myasthenia Gravis

Is NCT06106672 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies CNP-106 for myasthenia gravis.

Phase 1/2RecruitingCOUR Pharmaceutical Development Company, Inc.NCT06106672Data as of May 2026

Treatment: CNP-106Phase 1b/2a First-in-Human (FIH) clinical trial to assess the safety, tolerability, pharmacodynamics (PD), and efficacy of multiple ascending doses of CNP-106.

Check if I qualify

Extracted eligibility criteria

Prior therapy

Cannot have received: calcineurin inhibitor (tacrolimus)

Tacrolimus within 6 months prior to the first dosing

Cannot have received: antimetabolite (methotrexate)

Methotrexate within 5 half-lives or 90 days after last dose (whichever is longer)

Cannot have received: anti-FcRn inhibitor (efgartigimod)

Anti-FcRn inhibitors (ex. Efgartigimod) within 5 half-lives or 90 days after last dose (whichever is longer)

Cannot have received: C5 complement inhibitor (eculizumab)

C5 complement inhibitor (ex. Eculizumab) within 5 half-lives or 90 days after last dose (whichever is longer)

Cannot have received: anti-CD20 (rituximab)

Anti-CD20 (ex. Rituximab) within 5 half-lives for 90 days after last dose (whichever is longer)

Cannot have received: immunoglobulin (SCIg, IVIg)

immunoglobulins given SC or IV (SCIg or IVIg) within 4 weeks before Screening

Cannot have received: plasmapheresis/plasma exchange

plasmapheresis/plasma exchange (PE) within 4 weeks before Screening

Cannot have received: investigational therapy

Exception: other than CNP-106

investigational therapy other than CNP-106 within 28 days or 5 half-lives, whichever is longer, prior to Screening

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Barrow Neurological Institute · Phoenix, Arizona
  • Neuromuscular Clinic and Research Center · Phoenix, Arizona
  • Infusion for Health · Brea, California
  • University of California, Irvine · Orange, California
  • Yale University · New Haven, Connecticut

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

Could you qualify for this trial?

Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.

Check if I qualify