OncoMatch/Clinical Trials/NCT06106672
Evaluate the Safety, Tolerability, Pharmacodynamics and Efficacy of CNP-106 in Subjects With Myasthenia Gravis
Is NCT06106672 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies CNP-106 for myasthenia gravis.
Treatment: CNP-106 — Phase 1b/2a First-in-Human (FIH) clinical trial to assess the safety, tolerability, pharmacodynamics (PD), and efficacy of multiple ascending doses of CNP-106.
Check if I qualifyExtracted eligibility criteria
Prior therapy
Cannot have received: calcineurin inhibitor (tacrolimus)
Tacrolimus within 6 months prior to the first dosing
Cannot have received: antimetabolite (methotrexate)
Methotrexate within 5 half-lives or 90 days after last dose (whichever is longer)
Cannot have received: anti-FcRn inhibitor (efgartigimod)
Anti-FcRn inhibitors (ex. Efgartigimod) within 5 half-lives or 90 days after last dose (whichever is longer)
Cannot have received: C5 complement inhibitor (eculizumab)
C5 complement inhibitor (ex. Eculizumab) within 5 half-lives or 90 days after last dose (whichever is longer)
Cannot have received: anti-CD20 (rituximab)
Anti-CD20 (ex. Rituximab) within 5 half-lives for 90 days after last dose (whichever is longer)
Cannot have received: immunoglobulin (SCIg, IVIg)
immunoglobulins given SC or IV (SCIg or IVIg) within 4 weeks before Screening
Cannot have received: plasmapheresis/plasma exchange
plasmapheresis/plasma exchange (PE) within 4 weeks before Screening
Cannot have received: investigational therapy
Exception: other than CNP-106
investigational therapy other than CNP-106 within 28 days or 5 half-lives, whichever is longer, prior to Screening
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Barrow Neurological Institute · Phoenix, Arizona
- Neuromuscular Clinic and Research Center · Phoenix, Arizona
- Infusion for Health · Brea, California
- University of California, Irvine · Orange, California
- Yale University · New Haven, Connecticut
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
Could you qualify for this trial?
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