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OncoMatch/Clinical Trials/NCT06104553

A Trial of SHR-A1912 Combined With Other Therapies in B-cell Non-Hodgkin 's Lymphoma

Is NCT06104553 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies multiple treatments including SHR-A1912; R-Chemo and SHR-A1912; R-Chemo for b-cell non-hodgkin's lymphoma.

Phase 1/2RecruitingShanghai Hengrui Pharmaceutical Co., Ltd.NCT06104553Data as of May 2026

Treatment: SHR-A1912; R-Chemo · SHR-A1912; R-ChemoThis study aims to evaluate the safety, PK and preliminary anti-tumour activity of SHR-A1912 combined with other therapies in patients with B-cell non-Hodgkin 's lymphoma.

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Extracted eligibility criteria

Cancer type

Non-Hodgkin Lymphoma

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

Min 0 prior lines

Must have received: systemic anti-tumor therapy — relapsed/refractory cohort: at least one (≥ 1) line of prior systemic therapy

Relapsed and/or refractory disease after at least one (≥ 1) line of prior systemic therapy (relapsed/refractory cohort)

Cannot have received: autologous stem cell transplant

Exception: allowed if >12 weeks before first study treatment

Received autologous stem cell transplantation within 12 weeks before the first study treatment

Cannot have received: allogeneic stem cell transplant

previously received allogeneic stem cell transplantation

Cannot have received: CAR-T cell therapy

Exception: allowed if >12 weeks before first study treatment

received Car-T cell therapy within 12 weeks before the first study treatment

Cannot have received: anti-tumour treatment

Exception: allowed if >2 weeks before first study treatment

Received anti-tumour treatment within 2 weeks before the first study treatment

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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