OncoMatch/Clinical Trials/NCT06084234
National Liver Cancer Screening Trial
Is NCT06084234 recruiting? Yes, currently enrolling (Jun 2026). This Phase 4 trial studies non-drug interventions for carcinoma, hepatocellular.
The National Liver Cancer Screening Trial is an adaptive randomized phase IV Trial comparing ultrasound-based versus biomarker-based screening in 5500 patients with cirrhosis from any etiology or patients with chronic hepatitis B infection. Eligible patients will be randomized in a 1:1 fashion to Arm A using semi-annual ultrasound and AFP-based screening or Arm B using semi-annual screening using GALAD alone. Randomization will be stratified by sex, enrolling site, Child Pugh class (A vs. B), and HCC etiology (viral vs. non-viral). Patients will be recruited from 15 sites (mix of tertiary care and large community health systems) over a 3-year period, and the primary endpoint of the phase IV trial, reduction in late-stage HCC, will be assessed after 5.5 years.
Check if I qualifyExtracted eligibility criteria
Cancer type
Hepatocellular Carcinoma
Demographics
Lab requirements
Liver function
Cirrhosis from any etiology or chronic hepatitis B; Child Pugh C cirrhosis [excluded]
Cirrhosis from any etiology or chronic hepatitis B; Child Pugh C cirrhosis [excluded]
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- University of Southern California · Los Angeles, California
- Stanford University · Redwood City, California
- Kaiser Permanente · Roseville, California
- University of California, San Francisco · San Francisco, California
- Northwestern University · Chicago, Illinois
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT06084234 currently recruiting?
Yes, this trial is currently recruiting patients.
Is there an age limit?
Yes. Patients must be 85 years or younger.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages