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OncoMatch/Clinical Trials/NCT06051240

Lithium Treatment to Prevent Cognitive Impairment After Brain Radiotherapy

Is NCT06051240 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies Lithium for cognitive impairment.

Phase 2RecruitingRegion StockholmNCT06051240Data as of May 2026

Treatment: LithiumRandomized, placebo-controlled, double-blinded, parallel group clinical trial to investigate if 6 months of oral lithium tablets (S-lithium 0,5-1,0 mmol/l) will prevent cognitive decline after brain radiotherapy in pediatric brain tumor survivors. Primary outcome measure is Processing Speed Index (PSI) 2 years after start of study treatment.

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Extracted eligibility criteria

Cancer type

Glioblastoma

Prior therapy

Must have received: radiation therapy — cranial/craniospinal

Lab requirements

Kidney function

cystatin c derived glomerular filtration rate >= 60

Cardiac function

no cardiac failure or heart disease, including brugada syndrome (or family history thereof)

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