4 accounts found in public discussions of this study. These are individual experiences, not study results.
Getting a place on the study · Screening · Making the decision
Considering joining · November 2025 · Applied and was turned down on prior treatment history
A patient with advanced cancer wrote that he tried to join this study and was turned down because he had already had too many previous lines of treatment. He also described how people get considered at all: calling or emailing sites directly had got him nowhere, and the two studies he was considered for both came through referrals from one of his oncologists. A research nurse had told him much of it is being in the right place at the right time.
One person's experience · This person was not eligible
Read the original ↗Mayo Clinic Connect
Why this was linked to NCT06040541
He names the exact pair of study drugs this trial combines, with none of the additional chemotherapy the related study requires.
Side effects · Managing side effects · Communication with the team · Visit schedule
Participant · Carolina BioOncology Institute, North Carolina · January 2025 · Combination group, cycle 10
A second participant, in an early-phase dose group, described facial and scalp skin problems and brief nausea after dosing. They tried an oral antibiotic, a topical gel and oils for the rash, and said they were otherwise able to carry on with normal activities. They suggested contacting study sites directly to ask which dose groups were still open.
The original post names a specific study drug dose. We have left it out — doses in an early-phase study are assigned by group and change as the study runs.
This was posted more than 18 months ago. Study requirements and visit schedules change — confirm anything practical with the study team.
One person's experience · May be specific to this site · The study may have changed since
Read the original ↗Mayo Clinic Connect
Why this was linked to NCT06040541
The participant names the exact pair of study drugs, the early-phase dose group and a site that runs this study.
Visit schedule · Side effects · Managing side effects
Participant · January 2025 · Combination group, after four cycles
A participant wrote that each treatment cycle lasted three weeks. They described a facial rash that was severe at first, along with scalp and mouth soreness, diarrhoea, a modest drop in appetite and little nausea. Their study team prescribed an oral antibiotic and a topical gel for the rash and an anti-nausea medicine, and they found smaller meals helped.
The original post also describes how the person's cancer responded. We have left that out because one person's result is not evidence either way. Read the original for the full post.
This was posted more than 18 months ago. Study requirements and visit schedules change — confirm anything practical with the study team.
One person's experience · The study may have changed since
Read the original ↗Mayo Clinic Connect
Why this was linked to NCT06040541
The participant describes the exact two-drug combination this study tests, without the additional chemotherapy that the other study of these drugs requires.
Screening · Making the decision · Side effects
Caregiver · January 2025 · Waiting to hear whether their family member qualifies
A caregiver wrote that their mother, who has KRAS G12D pancreatic cancer, was waiting to learn whether she qualified. After several earlier chemotherapy regimens, the family was particularly worried about rash, nausea and loss of appetite.
This was posted more than 18 months ago. Study requirements and visit schedules change — confirm anything practical with the study team.
One person's experience · May be specific to this site · Describes planning, not treatment
Read the original ↗Mayo Clinic Connect
Why this was linked to NCT06040541
The caregiver describes the same two-drug study and a treatment history that fits this trial rather than the related combination study.
These are paraphrased from public posts and articles, each linked to its source. We check that a post is about this study, but we cannot verify what it describes. Nothing here is medical advice, and none of it should be read as evidence that a treatment works.