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OncoMatch/Clinical Trials/NCT06040541

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

Is NCT06040541 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies multiple treatments including RMC-9805 and RMC-6236 for non-small cell lung cancer (nsclc).

Phase 1RecruitingRevolution Medicines, Inc.NCT06040541Data as of May 2026

Treatment: RMC-9805 · RMC-6236This study is to evaluate the safety and tolerability of RMC-9805 as monotherapy and in combination with RMC-6236 in adults with KRAS G12D-mutant solid tumors.

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Extracted eligibility criteria

Cancer type

Non-Small Cell Lung Carcinoma

Colorectal Cancer

Pancreatic Cancer

Tumor Agnostic

Biomarker criteria

Required: KRAS g12d mutation

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

Min 1 prior line

Must have received: standard therapy (including targeted therapy) appropriate for tumor type and stage

Received and progressed or been intolerant to prior standard therapy (including targeted therapy) appropriate for tumor type and stage

Cannot have received: KRAS G12D inhibitor

previously treated with an investigational KRAS G12D inhibitor

Cannot have received: pan- or multi-RAS inhibitor

previously treated with...pan- or multi-RAS inhibitor

Cannot have received: direct RAS-targeted therapy (e.g., degraders and inhibitors)

prior therapy with any direct RAS-targeted therapy (eg, degraders and inhibitors)

Lab requirements

Blood counts

Kidney function

Liver function

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • University of California, Davis Comprehensive Cancer Center · Sacramento, California
  • Smilow Cancer Hospital (Yale University) · New Haven, Connecticut
  • Florida Cancer Specialists · Sarasota, Florida
  • Lee Moffitt Cancer Center · Tampa, Florida
  • Johns Hopkins University · Baltimore, Maryland

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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