OncoMatch/Clinical Trials/NCT06040541
Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors
Is NCT06040541 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies multiple treatments including RMC-9805 and RMC-6236 for non-small cell lung cancer (nsclc).
Treatment: RMC-9805 · RMC-6236 — This study is to evaluate the safety and tolerability of RMC-9805 as monotherapy and in combination with RMC-6236 in adults with KRAS G12D-mutant solid tumors.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Small Cell Lung Carcinoma
Colorectal Cancer
Pancreatic Cancer
Tumor Agnostic
Biomarker criteria
Required: KRAS g12d mutation
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: standard therapy (including targeted therapy) appropriate for tumor type and stage
Received and progressed or been intolerant to prior standard therapy (including targeted therapy) appropriate for tumor type and stage
Cannot have received: KRAS G12D inhibitor
previously treated with an investigational KRAS G12D inhibitor
Cannot have received: pan- or multi-RAS inhibitor
previously treated with...pan- or multi-RAS inhibitor
Cannot have received: direct RAS-targeted therapy (e.g., degraders and inhibitors)
prior therapy with any direct RAS-targeted therapy (eg, degraders and inhibitors)
Lab requirements
Blood counts
Kidney function
Liver function
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- University of California, Davis Comprehensive Cancer Center · Sacramento, California
- Smilow Cancer Hospital (Yale University) · New Haven, Connecticut
- Florida Cancer Specialists · Sarasota, Florida
- Lee Moffitt Cancer Center · Tampa, Florida
- Johns Hopkins University · Baltimore, Maryland
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
Could you qualify for this trial?
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