OncoMatch/Clinical Trials/NCT06010888
Fruquintinib With mFOLFOX6/FOLFIRI as First-Line Therapy for Conversion Surgery in mCRC
Is NCT06010888 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies Fruquintinib+mFOLFOX6/FOLFIRI for colorectal cancer.
Treatment: Fruquintinib+mFOLFOX6/FOLFIRI — The goal of this clinical trial is to learn about the efficacy and safety of Fruquintinib with mFOLFOX6/FOLFIRI in patients with mCRC. The main question it aims to answer is: The conversion surgery rate of the therapy mentioned above. The ORR, R0 surgery rate, DCR, PFS, OS, and safety will be evaluated.
Check if I qualifyExtracted eligibility criteria
Cancer type
Colorectal Cancer
Biomarker criteria
Required: KRAS mutation status determined
RAS/BRAF mutation status ... should be determined before enrollment.
Required: NRAS mutation status determined
RAS/BRAF mutation status ... should be determined before enrollment.
Required: BRAF mutation status determined
RAS/BRAF mutation status ... should be determined before enrollment.
Required: UGT1A1 *28/*6 gene polymorphism typing determined
UGT1A1*28/*6 gene polymorphism typing should be determined before enrollment.
Disease stage
Metastatic disease required
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: systemic anti-tumor therapy
Exception: neoadjuvant/adjuvant therapy allowed if >6 months since last chemotherapy to recurrence or progression
Have not received systematic anti-tumor therapy before; Patients who have received neoadjuvant/adjuvant therapy may be screened from the time of last chemotherapy to recurrence or progression more than 6 months.
Lab requirements
Blood counts
ANC ≥1.5×10^9/L; Platelet ≥100×10^9/L; Hemoglobin ≥9g/dL; Serum albumin ≥2.5g/dL
Kidney function
Serum creatinine ≤1.5 × ULN or creatinine clearance > 60 mL/min (Cockcroft-Gault)
Liver function
Total bilirubin ≤1.5 × ULN; ALT and AST≤2.5 × ULN, if there is liver metastasis, ALT and AST≤5 × ULN
The function of vital organs meets the following requirements ... (see full text for details)
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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