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OncoMatch/Clinical Trials/NCT06010329

A Study to Evaluate the Efficacy and Safety of Sutetinib Maleate Capsule in Locally Advanced or Metastatic NSCLC

Is NCT06010329 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies Sutetinib Maleate Capsule for non-small cell lung cancer.

Phase 2RecruitingTeligene USNCT06010329Data as of May 2026

Treatment: Sutetinib Maleate CapsuleThe main objective of the study will be to evaluate the efficacy of sutetinib maleate capsules in participants with locally advanced or metastatic non-small cell lung cancer NSCLC (uncommon EGFR mutations only).

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Extracted eligibility criteria

Cancer type

Non-Small Cell Lung Carcinoma

Biomarker criteria

Required: EGFR uncommon mutation

Performance status

ECOG 0–2(Ambulatory, capable of self-care)

Prior therapy

Cannot have received: EGFR tyrosine kinase inhibitor

Exception: Cohort 1: ever used EGFR TKI; Cohort 2: any second generation EGFR TKI

Participant ever used the epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR TKI) for anti-tumor therapy prior to enrollment (Cohort 1), or second generation EGFR TKI (Cohort 2)

Cannot have received: systemic anti-tumor therapy

Any systemic anti-tumor therapy such as chemotherapy and radiation therapy (including curative radiotherapy or spinal radiotherapy portion >30%) used within 3 weeks prior to enrollment; immunotherapy within 4 weeks; any palliative radiotherapy for non-target lesions used to relieve symptoms and traditional Chinese medicines indicated for the tumor within 2 weeks prior to enrollment; Cohort 2: any EGFR TKIs within 5 half-lives.

Lab requirements

Blood counts

adequate bone marrow reserve

Kidney function

adequate renal function

Liver function

adequate hepatic function

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Oncology Physicians Network Healthcare · Glendale, California
  • University of California San Diego Moores Cancer Center · La Jolla, California
  • Moffitt Cancer Center · Tampa, Florida
  • University Cancer & Blood Center (UCBC) - Athens · Athens, Georgia
  • Mission Cancer + Blood - Mission Cancer Foundation · Des Moines, Iowa

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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