OncoMatch/Clinical Trials/NCT05995041
Universal CAR-T Cells Targeting AML
Is NCT05995041 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies CLL-1, CD33, CD38 and/or CD123-specific universal CAR- T cells for acute myeloid leukemia.
Treatment: CLL-1, CD33, CD38 and/or CD123-specific universal CAR- T cells — The purpose of this clinical trial is to assess the feasibility, safety and efficacy of universal CAR T-cell products targeting CLL-1, CD33, CD38 and CD123 in patients with relapsed and refractory AML. The study also aims to learn more about the function of the universal CAR T cells and their persistency in AML patients.
Check if I qualifyExtracted eligibility criteria
Cancer type
Acute Myeloid Leukemia
Biomarker criteria
Required: CLEC12A overexpression
Confirmed expression of CLL-1, CD123, CD38 and/or CD33 in AML blasts by immuno-histochemical staining or flow cytometry
Required: IL3RA overexpression
Confirmed expression of CLL-1, CD123, CD38 and/or CD33 in AML blasts by immuno-histochemical staining or flow cytometry
Required: CD38 overexpression
Confirmed expression of CLL-1, CD123, CD38 and/or CD33 in AML blasts by immuno-histochemical staining or flow cytometry
Required: CD33 overexpression
Confirmed expression of CLL-1, CD123, CD38 and/or CD33 in AML blasts by immuno-histochemical staining or flow cytometry
Prior therapy
Cannot have received: gene therapy
Lab requirements
Blood counts
Hgb≥80g/L
Kidney function
creatinine ≤ 2.5 × upper limit of normal
Liver function
AST and ALT ≤ 3 × upper limit of normal, total bilirubin ≤ 2.0mg/dL
Cardiac function
cardiac ejection fraction ≥ 50%, oxygen saturation ≥ 90%
Adequate bone marrow, liver and renal function as assessed by the following laboratory requirements: cardiac ejection fraction ≥ 50%, oxygen saturation ≥ 90%, creatinine ≤ 2.5 × upper limit of normal, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3 × upper limit of normal, total bilirubin ≤ 2.0mg/dL. Hgb≥80g/L.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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