OncoMatch/Clinical Trials/NCT05990803
A Study of BL-B01D1, SI-B003 and BL-B01D1+SI-B003 in Patients With Recurrent or Metastatic Cervical Cancer and Other Gynecological Malignancies
Is NCT05990803 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies multiple treatments including BL-B01D1 and SI-B003 for cervical cancer.
Treatment: BL-B01D1 · SI-B003 — Objective: To explore the efficacy, safety and tolerability of BL-B01D1, SI-B003 and BL-B01D1+SI-B003 in patients with recurrent or metastatic cervical cancer and other gynecological malignancies, and to further explore the optimal dose and mode of combination.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Cervical Cancer
Performance status
ECOG 0–1(Restricted strenuous activity)
Demographics
Prior therapy
Must have received: standard treatment
after failure or intolerance to standard treatment or for which no standard treatment is available
Cannot have received: antibody-drug conjugate with topoisomerase I inhibitor
Prior treatment with an ADC drug with a topoisomerase I inhibitor as a toxin
Cannot have received: antineoplastic therapy
Exception: within 4 weeks or 5 half-lives before the first dose
Use of antineoplastic therapy within 4 weeks or 5 half-lives before the first dose
Cannot have received: mitomycin (mitomycin)
Exception: within 6 weeks before the first dose
Mitomycin and nitrosoureas were administered within 6 weeks before the first dose
Cannot have received: nitrosoureas (nitrosoureas)
Exception: within 6 weeks before the first dose
Mitomycin and nitrosoureas were administered within 6 weeks before the first dose
Cannot have received: oral fluorouracil (oral fluorouracil)
Exception: within 2 weeks before the first dose
Oral fluorouracil or palliative radiotherapy within 2 weeks before the first dose
Cannot have received: palliative radiotherapy
Exception: within 2 weeks before the first dose
Oral fluorouracil or palliative radiotherapy within 2 weeks before the first dose
Cannot have received: immunomodulatory drug
Exception: within 14 days before the first dose of study drug (Cohort_B, Cohort_C only)
Cohort_B, Cohort_C, who had received an immunomodulatory drug within 14 days before the first dose of study drug
Lab requirements
Cardiac function
no severe cardiac dysfunction, left ventricular ejection fraction ≥50%
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT05990803 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior antibody-drug conjugate with topoisomerase I inhibitor, antineoplastic therapy, mitomycin disqualifies patients from enrollment.
Is there an age limit?
Yes. Patients must be 75 years or younger.
Is this trial open to male patients?
No. This trial enrolls female patients only.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages