OncoMatch/Clinical Trials/NCT05990803
A Study of BL-B01D1, SI-B003 and BL-B01D1+SI-B003 in Patients With Recurrent or Metastatic Cervical Cancer and Other Gynecological Malignancies
Is NCT05990803 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including BL-B01D1 and SI-B003 for cervical cancer.
Treatment: BL-B01D1 · SI-B003 — Objective: To explore the efficacy, safety and tolerability of BL-B01D1, SI-B003 and BL-B01D1+SI-B003 in patients with recurrent or metastatic cervical cancer and other gynecological malignancies, and to further explore the optimal dose and mode of combination.
Check if I qualifyExtracted eligibility criteria
Cancer type
Cervical Cancer
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: standard treatment
after failure or intolerance to standard treatment or for which no standard treatment is available
Cannot have received: antibody-drug conjugate with topoisomerase I inhibitor
Prior treatment with an ADC drug with a topoisomerase I inhibitor as a toxin
Cannot have received: antineoplastic therapy
Exception: within 4 weeks or 5 half-lives before the first dose
Use of antineoplastic therapy within 4 weeks or 5 half-lives before the first dose
Cannot have received: mitomycin (mitomycin)
Exception: within 6 weeks before the first dose
Mitomycin and nitrosoureas were administered within 6 weeks before the first dose
Cannot have received: nitrosoureas (nitrosoureas)
Exception: within 6 weeks before the first dose
Mitomycin and nitrosoureas were administered within 6 weeks before the first dose
Cannot have received: oral fluorouracil (oral fluorouracil)
Exception: within 2 weeks before the first dose
Oral fluorouracil or palliative radiotherapy within 2 weeks before the first dose
Cannot have received: palliative radiotherapy
Exception: within 2 weeks before the first dose
Oral fluorouracil or palliative radiotherapy within 2 weeks before the first dose
Cannot have received: immunomodulatory drug
Exception: within 14 days before the first dose of study drug (Cohort_B, Cohort_C only)
Cohort_B, Cohort_C, who had received an immunomodulatory drug within 14 days before the first dose of study drug
Lab requirements
Cardiac function
no severe cardiac dysfunction, left ventricular ejection fraction ≥50%
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualify