OncoMatch/Clinical Trials/NCT05987644
Delayed or Upfront Brain RAdiotherapy in Treatment naïve Lung Cancer Patients With Asymptomatic or Minimally Symptomatic Brain Metastases and ALK rEarrangements
Is NCT05987644 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies Alectinib for lung cancer.
Treatment: Alectinib — This study will consist of a Phase 1b and Phase 2 portion. The Phase 1b portion will enroll first followed by the Phase 2 portion. Each cycle of treatment = 28 days. Subjects will receive alectinib twice daily. Those in the Phase 1b portion will receive alectinib alone. Those in Phase 2 Arm A will receive alectinib alone. Those in Phase 2, Arm B will receive SRS + alectinib. A maximum of 25 cycles (2 years) of alectinib may be administered on study.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Small Cell Lung Carcinoma
Biomarker criteria
Required: ALK rearrangement
Disease stage
Required: Stage IV
Metastatic disease required
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: investigational drug
Treatment with any investigational drug within 28 days prior to registration
Lab requirements
Blood counts
Demonstrate adequate organ function as defined in the protocol. All screening labs to be obtained within 14 days prior to registration.
Kidney function
Demonstrate adequate organ function as defined in the protocol. All screening labs to be obtained within 14 days prior to registration.
Liver function
Demonstrate adequate organ function as defined in the protocol. All screening labs to be obtained within 14 days prior to registration.
Demonstrate adequate organ function as defined in the protocol. All screening labs to be obtained within 14 days prior to registration.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Stanford University · Stanford, California
- University of Colorado Cancer Center · Aurora, Colorado
- Ohio State University Comprehensive Cancer Center · Columbus, Ohio
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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