OncoMatch/Clinical Trials/NCT05983276
Decitabine and Selinexor in Combination to Reverse Drug Resistance With Standard Chemotherapy in Ovarian Cancer
Is NCT05983276 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Decitabine and Carboplatin for ovarian cancer.
Treatment: Decitabine · Carboplatin · Paclitaxel · Selinexor — The goal of this clinical trial is to learn about the side effects and effectiveness of this novel four-drug combination of chemotherapy (decitabine, selinexor, carboplatin and paclitaxel) on patients with relapsed ovarian, fallopian or primary peritoneal carcinoma. Recently the investigators have found that the combination of decitabine and selinexor, two Food and Drug Administration (FDA) approved chemotherapy agents, may prevent or reverse the development of drug resistance and further the remissions and duration of remissions with standard ovarian cancer chemotherapy with carboplatin and paclitaxel. As decitabine and selinexor are not FDA approved for the participant's cancer, these agents are investigational.
Check if I qualifyExtracted eligibility criteria
Cancer type
Ovarian Cancer
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Must have received: platinum-based chemotherapy
failed or relapsed after a platinum and taxane containing combination
Must have received: taxane
failed or relapsed after a platinum and taxane containing combination
Cannot have received: Selinexor or another XPO1 inhibitor
must not have received Selinexor or another XPO1 inhibitor previously
Cannot have received: chemotherapy
must not have had prior chemotherapy or radiation therapy
Cannot have received: radiation therapy
must not have had prior chemotherapy or radiation therapy
Lab requirements
Kidney function
adequate renal function
Liver function
adequate hepatic function
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Loyola University Medical Center · Maywood, Illinois
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