OncoMatch/Clinical Trials/NCT05979961
Phase III Trial of Concurrent Chemotherapy Alone in Patients With Low-risk Nasopharyngeal Carcinoma
Is NCT05979961 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies gemcitabine and cisplatin (Induction chemotherapy) for nasopharyngeal carcinoma.
Treatment: gemcitabine and cisplatin (Induction chemotherapy) — The purpose of this study is to compare concurrent chemoradiotherapy (CCRT) alone with induction chemotherapy (gemcitabine+cisplatin) plus CCRT in patients with low-risk locoregionally advanced nasopharyngeal carcinoma(NPC).
Check if I qualifyExtracted eligibility criteria
Cancer type
Head and Neck Squamous Cell Carcinoma
Biomarker criteria
Required: EBV plasma EB Virus DNA <4000 copies/ml (<4000 copies/ml)
pretreatment plasm EB Virus DNA<4000copies/ml
Disease stage
Required: Stage III, IVA
Excluded: Stage T4N2, ANYTN3
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: radiation therapy
Exception: except for non-melanomatous skin cancers outside intended RT treatment volume
History of previous RT (except for non-melanomatous skin cancers outside intended RT treatment volume)
Cannot have received: chemotherapy
Prior chemotherapy or surgery (except diagnostic) to primary tumor or nodes
Cannot have received: surgery
Exception: except diagnostic
Prior chemotherapy or surgery (except diagnostic) to primary tumor or nodes
Lab requirements
Blood counts
leucocyte count ≥ 4000/μL, hemoglobin ≥ 90g/L and platelet count ≥ 100000/μL
Kidney function
creatinine clearance ≥ 60 ml/min
Liver function
ALT, AST < 1.5×ULN concomitant with ALP < 2.5×ULN, and bilirubin < ULN
Adequate marrow: leucocyte count ≥ 4000/μL, hemoglobin ≥ 90g/L and platelet count ≥ 100000/μL. Normal liver function test: ALT, AST < 1.5×ULN concomitant with ALP < 2.5×ULN, and bilirubin < ULN. Adequate renal function: creatinine clearance ≥ 60 ml/min.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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