OncoMatch/Clinical Trials/NCT05968690
Naltrexone and Propranolol Combined With Immunotherapy
Is NCT05968690 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies multiple treatments including Propranolol and Naltrexone for advanced melanoma.
Treatment: Propranolol · Naltrexone — Various forms of stress can promote cancer development and growth and negatively impact the immune system's response to tumors. Beta-adrenergic and opioid receptors co-exist in many cells including immune cells and are integral components of the body's response to stress. Pre-clinical studies have demonstrated that dual blockade of these receptors can decrease tumor growth and modulate the anti-tumor immune response. This clinical trial investigates the safety and potential therapeutic benefits of combining a beta-adrenergic blocker (propranolol) and an opioid receptor antagonist (naltrexone) with immune checkpoint inhibitors in patients with advanced melanoma.
Check if I qualifyExtracted eligibility criteria
Cancer type
Melanoma
Disease stage
Required: Stage III, IV
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: investigational agent
Receipt of any other investigational agents or participation in a study of an investigational agent or use of an investigational device within four weeks of the first dose of treatment.
Lab requirements
Blood counts
ANC >1500/mcL; platelets >100,000/mcL; hemoglobin >9 g/dL; albumin >2.5 mg/dL
Liver function
AST and ALT <2.5x ULN; serum total bilirubin <1.5x ULN or direct bilirubin < ULN for subjects with total bilirubin >1.5x ULN.
Normal organ function, defined as: 1. Absolute neutrophil count (ANC) >1500/mcL 2. Platelets >100,000/mcL 3. Hemoglobin (Hb) >9 g/dL 4. Albumin >2.5 mg/dL 5. AST and ALT <2.5x ULN 6. Serum total bilirubin <1.5x ULN or direct bilirubin < ULN for subjects with total bilirubin >1.5x ULN.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Rutgers Cancer Institute of New Jersey · New Brunswick, New Jersey
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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