OncoMatch/Clinical Trials/NCT05962242
HPV DNA-Guided Radiotherapy De-intensification of Head and Neck Squamous Cell Carcinoma
Is NCT05962242 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies non-drug interventions for squamous cell carcinoma of the oropharynx.
The study will evaluate the safety and effectiveness of a lower than standard dose of radiation for definitive or adjuvant treatment of head and neck squamous cell carcinomas.
Check if I qualifyExtracted eligibility criteria
Biomarker criteria
Required: CDKN2A p16 positive (positive)
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: radiation therapy
Prior history of radiotherapy to the head and/or neck
Cannot have received: surgery
Exception: Participant is eligible if the gross tumor was not completely removed (incomplete oncologic surgery)
Had surgery for oropharyngeal cancer within 8 months of enrollment unless it was an incomplete oncologic surgery
Lab requirements
Liver function
Hepatic insufficiency as determined by the treating clinician resulting in clinical jaundice and/or coagulation effects or severe liver dysfunction [excluded]
Cardiac function
Unstable angina and/or congestive heart failure requiring hospitalization up to 180 days before registration; Transmural myocardial infarction up to 180 days before registration [excluded]
Unstable angina and/or congestive heart failure requiring hospitalization up to 180 days before registration; Transmural myocardial infarction up to 180 days before registration; Hepatic insufficiency as determined by the treating clinician resulting in clinical jaundice and/or coagulation effects or severe liver dysfunction
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Miami Cancer Institute · Miami, Florida
- University of Virginia · Charlottesville, Virginia
- Eastern Virginia Medical School · Norfolk, Virginia
- Bon Secours · Richmond, Virginia
- Virginia Commonwealth University · Richmond, Virginia
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
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