OncoMatch/Clinical Trials/NCT05952453
Newly Diagnosed Stage III/IV Ovarian Cancer, Neoadjuvant Carbo/Taxol/Pembro, Maintenance Olaparib/Pembro
Is NCT05952453 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Carboplatin and olaparibp, embro for ovarian cancer.
Treatment: Carboplatin · olaparibp, embro — this is a trial evaluating three chemotherapy agents in patients with newly diagnosed ovarian cancer patients that are Stage III or Stage IV prior to surgery to remove the tumor. After surgery there will be additional chemotherapy given.
Check if I qualifyExtracted eligibility criteria
Cancer type
Ovarian Cancer
Disease stage
Required: Stage III, IV
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: systemic anti-cancer therapy
Participant has received prior treatment for advanced or metastatic OC, including radiation or systemic anti-cancer therapy (e.g., chemotherapy, hormonal therapy, immunotherapy, investigational therapy).
Cannot have received: PARP inhibitor (olaparib)
Participant has received prior therapy with olaparib or with any other PARP inhibitor.
Lab requirements
Blood counts
Absolute neutrophil count (ANC) ≥1500/μL; Platelets ≥100,000/μL; Hemoglobin ≥8.0 g/dL or ≥5.6 mmol/L
Kidney function
Creatinine OR measured or calculated creatinine clearance (GFR can also be used in place of creatinine or CrCl) ≤1.5 × ULN OR ≥51 mL/min for participant with creatinine levels >1.5 × institutional ULN
Liver function
Total bilirubin ≤1.5 ×ULN OR direct bilirubin ≤ULN for participants with total bilirubin levels >1.5 × ULN; AST (SGOT) and ALT (SGPT) ≤2.5 × ULN (≤5 × ULN for participants with liver metastases)
Participant has adequate organ function as follows; ... see full criteria
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- O'Neal Comprehensive Cancer Center at UAB · Birmingham, Alabama
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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