OncoMatch

OncoMatch/Clinical Trials/NCT05950165

A Study to Assess Safety and Efficacy of CHO-H01 as a Single Agent/Combined With Lenalidomide in Subjects With Refractory or Relapsed Non-Hodgkin's Lymphoma

Is NCT05950165 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies multiple treatments including CHO-H01 and CHO-H01 at RP2D for non-hodgkin lymphoma.

Phase 1/2RecruitingCho Pharma Inc.NCT05950165Data as of May 2026

Treatment: CHO-H01 · CHO-H01 at RP2D · LenalidomideThis is a 2-part study. Part 1/Phase 1 of the study will be conducted to determine the safety and tolerability of CHO-H01 in subjects with relapsed/refractory CD20+ non-Hodgkin's lymphoma. It will also determine maximum tolerated dose (MTD) and recommended phase II dose (RP2D). Part 2/Phase 2a will assess the anticancer activity and safety of CHO-H01 plus lenalidomide in subjects with low-grade relapsed/refractory CD20+ non-Hodgkin's lymphoma.

Check if I qualify

Extracted eligibility criteria

Cancer type

Non-Hodgkin Lymphoma

Biomarker criteria

Required: MS4A1 overexpression (CD20+)

histologically (laboratory test) confirmed CD20 + non-Hodgkin's lymphoma

Performance status

ECOG 0–2(Ambulatory, capable of self-care)

Prior therapy

Cannot have received: anti-PD-1 therapy

Subjects who have received anti-programmed death-ligand 1 (PD-L1), programmed cell death 1 (PD-1), or cytotoxic T-lymphocyte associated protein 4 (CTLA-4) therapy.

Cannot have received: autologous stem cell transplant

Exception: within 100 days prior to CHO-H01 therapy

Subjects who have completed an autologous stem cell transplant within 100 days prior to CHO-H01 therapy

Cannot have received: allogeneic stem cell transplant

or an allogeneic stem cell transplant

Cannot have received: radiation therapy

Exception: within 28 days prior to CHO-H01 administration

Subjects who have had radiation therapy...within 28 days prior to CHO-H01 administration.

Cannot have received: systemic corticosteroids

Exception: at a daily dose higher than 15 mg prednisone or equivalent within 14 days prior to the first administration of CHO-H01; topical, inhaled, nasal, and ophthalmic steroids are allowed

Subjects who have received (or are receiving) systemic corticosteroids: At a daily dose higher than 15 mg prednisone or equivalent within 14 days prior to the first administration of CHO-H01; Topical, inhaled, nasal, and ophthalmic steroids are allowed.

Cannot have received: live vaccination

Exception: within 28 days prior to CHO-H01 administration

Subjects who have had...live vaccinations within 28 days prior to CHO-H01 administration.

Lab requirements

Blood counts

adequate bone marrow function required

Kidney function

adequate renal function required

Liver function

adequate hepatic function required

Cardiac function

adequate cardiac function: without clinically significant and/or uncontrolled heart disease

Have adequate cardiac function: without clinically significant and/or uncontrolled heart disease. Inadequate bone marrow, hepatic or renal function [excluded].

Structured fields extracted by AI. May contain errors — verify against the official protocol.

Could you qualify for this trial?

Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.

Check if I qualify