OncoMatch/Clinical Trials/NCT05950165
A Study to Assess Safety and Efficacy of CHO-H01 as a Single Agent/Combined With Lenalidomide in Subjects With Refractory or Relapsed Non-Hodgkin's Lymphoma
Is NCT05950165 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies multiple treatments including CHO-H01 and CHO-H01 at RP2D for non-hodgkin lymphoma.
Treatment: CHO-H01 · CHO-H01 at RP2D · Lenalidomide — This is a 2-part study. Part 1/Phase 1 of the study will be conducted to determine the safety and tolerability of CHO-H01 in subjects with relapsed/refractory CD20+ non-Hodgkin's lymphoma. It will also determine maximum tolerated dose (MTD) and recommended phase II dose (RP2D). Part 2/Phase 2a will assess the anticancer activity and safety of CHO-H01 plus lenalidomide in subjects with low-grade relapsed/refractory CD20+ non-Hodgkin's lymphoma.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Hodgkin Lymphoma
Biomarker criteria
Required: MS4A1 overexpression (CD20+)
histologically (laboratory test) confirmed CD20 + non-Hodgkin's lymphoma
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: anti-PD-1 therapy
Subjects who have received anti-programmed death-ligand 1 (PD-L1), programmed cell death 1 (PD-1), or cytotoxic T-lymphocyte associated protein 4 (CTLA-4) therapy.
Cannot have received: autologous stem cell transplant
Exception: within 100 days prior to CHO-H01 therapy
Subjects who have completed an autologous stem cell transplant within 100 days prior to CHO-H01 therapy
Cannot have received: allogeneic stem cell transplant
or an allogeneic stem cell transplant
Cannot have received: radiation therapy
Exception: within 28 days prior to CHO-H01 administration
Subjects who have had radiation therapy...within 28 days prior to CHO-H01 administration.
Cannot have received: systemic corticosteroids
Exception: at a daily dose higher than 15 mg prednisone or equivalent within 14 days prior to the first administration of CHO-H01; topical, inhaled, nasal, and ophthalmic steroids are allowed
Subjects who have received (or are receiving) systemic corticosteroids: At a daily dose higher than 15 mg prednisone or equivalent within 14 days prior to the first administration of CHO-H01; Topical, inhaled, nasal, and ophthalmic steroids are allowed.
Cannot have received: live vaccination
Exception: within 28 days prior to CHO-H01 administration
Subjects who have had...live vaccinations within 28 days prior to CHO-H01 administration.
Lab requirements
Blood counts
adequate bone marrow function required
Kidney function
adequate renal function required
Liver function
adequate hepatic function required
Cardiac function
adequate cardiac function: without clinically significant and/or uncontrolled heart disease
Have adequate cardiac function: without clinically significant and/or uncontrolled heart disease. Inadequate bone marrow, hepatic or renal function [excluded].
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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