OncoMatch/Clinical Trials/NCT05949944
Linperlisib in Combination With CHOP in Previously Untreated Peripheral T-Cell Lymphoma
Is NCT05949944 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies Linperlisib in combination with CHOP for peripheral t-cell lymphoma.
Treatment: Linperlisib in combination with CHOP — This phase Ib/II, single arm, open label, multicenter study is conducted to evaluate the efficacy and safety of linperlisib in combination with CHOP for newly diagnosed PTCL patients, and explore the reasonable dosage of linperlisib when combined with CHOP regimen.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Hodgkin Lymphoma
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: PI3K inhibitor
Received PI3K inhibitor treatment before enrollment
Lab requirements
Blood counts
Adequate bone marrow function required
Kidney function
No renal failure requiring hemodialysis or peritoneal dialysis
Liver function
No decompensated cirrhosis (Child Pugh B or C); no clinically significant liver disease; viral hepatitis B and C must be controlled as specified
Cardiac function
No ≥ Level 2 myocardial ischemia or infarction, arrhythmia (including QTc ≥ 450ms (male), QTc ≥ 470ms (female)), or ≥ Level 2 congestive heart failure (NYHA classification)
Adequate bone marrow and organ functions; Poor blood pressure control (systolic blood pressure ≥ 150mm Hg or diastolic blood pressure ≥ 100 mmHg); ≥ Level 2 myocardial ischemia or infarction, arrhythmia (including QTc ≥ 450ms (male), QTc ≥ 470ms (female)), and ≥ Level 2 congestive heart failure (NYHA classification); Active interstitial pneumonia or other chronic lung diseases, leading to severe impairment of lung function, defined as FEV1 and DLCOc<60% of normal predicted values; Decompensated cirrhosis (Child Pugh liver function rating of B or C); Known clinically significant history of liver disease; Renal failure requiring hemodialysis or Peritoneal dialysis
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualify