OncoMatch/Clinical Trials/NCT05939661
A Multicenter Single-arm P2 to Evaluate Safety and Efficacy of the Total Neoadjuvant Therapy for cT2 Rectal Cancer
Is NCT05939661 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies Chemotherapy for rectal cancer.
Treatment: Chemotherapy — A multicenter single-arm phase 2 study to evaluate safety and efficacy of the total neoadjuvant therapy of short course radiation therapy followed by neoadjuvant oxaliplatin/fluorouracil-based chemotherapy (CAPOX) for cT2 rectal cancer
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Colorectal Cancer
Disease stage
Required: Stage CT2N0M0
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: extensive surgery
Exception: excluding CV port placement
extensive surgery (excluding CV port placement) within 4 weeks
Cannot have received: anticancer therapy
Any anticancer therapy within 4 weeks
Cannot have received: radiation therapy
Radiation within 4 weeks
Lab requirements
Blood counts
Neutrophil count: >= 1,500/mm3; Platelet count: >= 10.0 x 10^4 /mm3; Hemoglobin: >=9.0 g/dL
Kidney function
Serum creatinine: 1.5x or less than ULN or creatinine clearance: 45 mL/min or more
Liver function
Total bilirubin: 1.5x or less than ULN; AST, ALT, ALP: 2.5x or less than ULN
criteria for major organ function within 14 days prior to registration: Neutrophil count: >= 1,500/mm3; Platelet count: >= 10.0 x 10^4 /mm3; Hemoglobin: >=9.0 g/dL; Total bilirubin: 1.5x or less than ULN; AST, ALT, ALP: 2.5x or less than ULN; Serum creatinine: 1.5x or less than ULN or creatinine clearance: 45 mL/min or more
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT05939661 currently recruiting?
Yes, this trial is currently recruiting patients.
Can patients have received prior systemic therapy?
No. This trial requires treatment-naive patients — prior systemic therapy is an exclusion criterion.
What disease stage is eligible?
Stage CT2N0M0 is required.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages