OncoMatch/Clinical Trials/NCT05929222
Comparison Between Local Radiotherapy Alone or Combined With Obinutuzumab in Early Stage Follicular Lymphoma: the GAZEBO Trial From the Fondazione Italiana Linfomi
Is NCT05929222 recruiting? Yes, currently enrolling (Jun 2026). This Phase 3 trial studies non-drug interventions for follicular lymphoma.
Prospective, multicenter, open label, phase III randomized clinical trial in previously untreated Follicular Lymphoma in early stage. Patients will be randomized to receive Radiotherapy or Radiotherapy plus Obinutuzumab.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Hodgkin Lymphoma
Biomarker criteria
Required: BCL2 BCL2/IGH positive cells by PCR
Qualitative/quantitative PCR centralized assessment of BCL2/IGH positive cells in peripheral blood (PB), bone marrow (BM).
Required: BCL2 t(14;18) by FISH
Centralized revision of the lymph node biopsy with FISH for t(14;18)
Disease stage
Required: Stage IA, IIA, IE (Ann Arbor)
Excluded: Stage IIB, III, IV
Grade: IIIIIIA (WHO 2017)
Ann Arbor Stage IA or IIA (includible in one radiation field), or IE, non-bulky (<7 cm). Stage must be determined by PET/CT scan
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Lab requirements
Kidney function
creatinine clearance ≥ 40 ml/min (cockcroft-gault formula)
Liver function
ast and alt ≤ 3.0 x unl; bilirubin ≤1.5 x unl (unless due to gilbert's syndrome or non-hepatic origin)
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT05929222 currently recruiting?
Yes, this trial is currently recruiting patients.
Can patients have received prior systemic therapy?
No. This trial requires treatment-naive patients — prior systemic therapy is an exclusion criterion.
Does this trial require BCL2?
Yes, BCL2 BCL2/IGH positive cells by PCR is a required biomarker for enrollment.
Does this trial require BCL2?
Yes, BCL2 t(14;18) by FISH is a required biomarker for enrollment.
What disease stage is eligible?
Stage IA or IIA or IE is required.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages