OncoMatch/Clinical Trials/NCT05926063

Stopping Antibiotics After 3 Days for the Treatment of High-risk FEbrile Neutropenia

Is NCT05926063 recruiting? Yes, currently enrolling (May 2026). This Phase 4 trial studies non-drug interventions for neutropenia, febrile.

The goal of this clinical trial is to compare a short course of antibiotics in patients in whom no bacterial infection is found with the current "golden standard": long-term antibiotic treatment in adult hematology patients who develop neutropenic fever. The main question it aims to answer is: whether the short-term treatment is equally safe for patients, hence the name 'SAFE study'. Participants will be randomly assigned (randomized) to one of two treatment options once they develop neutropenic fever: short-term or long-term antibiotic treatment. An additional blood sample, urine sample and stool sample will be collected. Researchers will compare the short-term and the long-term antibiotic treatment groups to see if the short treatment is equally safe as the long-term treatment group.