OncoMatch

OncoMatch/Clinical Trials/NCT05919264

FOG-001 in Locally Advanced or Metastatic Solid Tumors

Is NCT05919264 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies multiple treatments for cancer.

Phase 1/2RecruitingParabilis Medicines, Inc.NCT05919264Data as of May 2026

Treatment: FOG-001 · mFOLFOX-6 · Nivolumab · Trifluridine/tipiracil · BevacizumabThe goal of this clinical trial is to determine if FOG-001 is safe and effective in participants with locally advanced or metastatic cancer.

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Extracted eligibility criteria

Cancer type

Colorectal Cancer

Tumor Agnostic

Hepatocellular Carcinoma

Prostate Cancer

Endometrial Cancer

Glioblastoma

Biomarker criteria

Required: APC loss-of-function mutation

Participants with tumors known to be negative for APC LoF mutations ... are not eligible

Required: CTNNB1 gain-of-function mutation

Participants with tumors known to be negative for ... CTNNB1 GoF mutations ... are not eligible

Disease stage

Required: Stage III, IV

Diagnosis of treatment-refractory advanced/metastatic solid tumor; locally advanced or metastatic non-MSI-H or non-dMMR CRC

Performance status

ECOG 0–1(Restricted strenuous activity)

Lab requirements

Blood counts

Kidney function

Liver function

Cardiac function

Unstable/inadequate cardiac function excluded

Adequate organ and marrow function. Unstable/inadequate cardiac function.

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Honor Health · Scottsdale, Arizona
  • Arizona Cancer Center at University of Arizona · Tucson, Arizona
  • Stanford Cancer Institute, Stanford University · Palo Alto, California
  • University of California San Francisco, Helen Diller Family Comprehensive Cancer Center · San Francisco, California
  • Sarcoma Oncology Center · Santa Monica, California

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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