OncoMatch/Clinical Trials/NCT05879146
Evaluation of the Response and Non-response of Nirogacestat in Desmoid Tumors- Clinical Study
Is NCT05879146 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies Nirogacestat for tumor.
Treatment: Nirogacestat — To learn about the safety and effects of an investigational drug called nirogacestat when given to participants with a desmoid tumor/aggressive fibromatosis
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Lab requirements
Blood counts
Absolute neutrophil count ≥ 1500 cells/μL; Platelets ≥ 100,000 μL; Hemoglobin ≥ 9 g/dL
Kidney function
If Creatinine > 1.5 x ULN then calculated creatinine clearance must be ≥ 60 mL/min (using the Cockcroft-Gault formula)
Liver function
Total bilirubin ≤ 1.5 × upper limit of normal (ULN) (isolated bilirubin > 1.5 x ULN is acceptable if bilirubin is fractionated and direct bilirubin < 35%); AST/ALT ≤ 2 × ULN
Cardiac function
New York Heart Association Functional Classification class 2B or better
Adequate organ and bone marrow function as defined by the following screening laboratory values: Absolute neutrophil count ≥ 1500 cells/μL; Platelets ≥ 100,000 μL; Hemoglobin ≥ 9 g/dL; Total bilirubin ≤ 1.5 × upper limit of normal (ULN) (isolated bilirubin > 1.5 x ULN is acceptable if bilirubin is fractionated and direct bilirubin < 35%); AST/ALT ≤ 2 × ULN; If Creatinine > 1.5 x ULN then calculated creatinine clearance must be ≥ 60 mL/min (using the Cockcroft-Gault formula). Cardiac: New York Heart Association Functional Classification class 2B or better
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- M D Anderson Cancer Center · Houston, Texas
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT05879146 currently recruiting?
Yes, this trial is currently recruiting patients.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
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