OncoMatch/Clinical Trials/NCT05877599
A Study of NT-175 in Adult Subjects With Unresectable, Advanced, and/or Metastatic Solid Tumors That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation
Is NCT05877599 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies Autologous, engineered T Cells targeting TP53 R175H for non-small cell lung cancer.
Treatment: Autologous, engineered T Cells targeting TP53 R175H — Phase I Study of NT-175, an autologous T cell therapy product genetically engineered to express an HLA-A\*02:01-restricted T cell receptor (TCR), targeting TP53 R175H mutant solid tumors.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Small Cell Lung Carcinoma
Head and Neck Squamous Cell Carcinoma
Colorectal Cancer
Pancreatic Cancer
Breast Carcinoma
Tumor Agnostic
Ovarian Cancer
Biomarker criteria
Required: TP53 R175H mutation
Tumors must harbor a TP53 R175H variant mutation
Required: HLA-A A*02:01 positive (at least 1 allele)
subject must be HLA-A*02:01 positive (at least 1 allele)
Disease stage
Required: Stage III, IV
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: systemic standard of care
after at least 1 line of approved systemic standard of care (SOC) treatment regimen
Cannot have received: adoptive cell and gene therapy
History of prior adoptive cell and gene therapy
Cannot have received: allogeneic stem cell transplant
allogeneic stem cell transplant
Cannot have received: solid organ transplantation
solid organ transplantation
Cannot have received: systemic therapy
Exception: within at least 2 weeks or 3 half-lives, whichever is shorter, prior to enrollment
Systemic therapy within at least 2 weeks or 3 half-lives, whichever is shorter, prior to enrollment
Lab requirements
Blood counts
Kidney function
Liver function
Cardiac function
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Research Site · Gilbert, Arizona
- Research Site · Duarte, California
- Research Site · Newport Beach, California
- Research Site · Santa Monica, California
- Research Site · Jacksonville, Florida
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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