OncoMatch/Clinical Trials/NCT05872724

Optimization of Postoperative Adjuvant Therapy for Cervical Cancer Based on MRD(Minimal Residual Disease)

Is NCT05872724 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Chemoradiotherapy + Adjuvant chemotherapy and Zimberelimab and Chemoradiotherapy (small pelvic) + Zimberelimab for cervical cancer.

Treatment: Chemoradiotherapy + Adjuvant chemotherapy and Zimberelimab · Chemoradiotherapy (small pelvic) + Zimberelimab — This study is a prospective cohort clinical trial that aims to investigate the safety and efficacy of a combined chemoradiotherapy and immunotherapy treatment for early postoperative cervical cancer. Specifically, this study seeks to evaluate the ability of MRD-based screening to detect and monitor changes in MRD status at different stages of treatment, its potential for use in monitoring patient recurrence rates and in prognosis evaluation. In addition, this study will investigate the safety and effectiveness of chemoradiotherapy combined with immunotherapy as a postoperative adjuvant therapy for patients identified to be at risk of early cervical cancer based on MRD screening.