OncoMatch/Clinical Trials/NCT05856773
Conventionally Fractionated vs. Hypofractionated Comprehensive Nodal Irradiation for Breast Cancer Using Pencil Beam Scanning Proton Therapy
Is NCT05856773 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies non-drug interventions for breast cancer.
The purpose of this research study is to learn more about the effects of using proton radiation therapy delivered over a shorter course of treatment (3 weeks) compared with a longer, standard course of treatment (5 weeks) for women with breast cancer who require radiotherapy to the breast/chest wall and regional lymph nodes.
Check if I qualifyExtracted eligibility criteria
Cancer type
Breast Carcinoma
Biomarker criteria
Excluded: BRCA1 mutation
Excluded: BRCA2 mutation
Disease stage
Required: Stage I, II, III
Excluded: Stage T4C, T4D
Stage I-III breast cancer; Exclusion: T4b or T4c disease or diagnosis of inflammatory breast cancer (T4d disease)
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Must have received: surgery
have undergone breast conserving surgery or mastectomy
Cannot have received: radiation therapy
Exception: if not overlapping with current target volume
Prior history of radiation therapy overlapping with current target volume (including intraoperative brachytherapy, interstitial catheter brachytherapy, balloon brachytherapy, external beam radiation therapy)
Cannot have received: explant surgery or implant removal due to infection or wound healing issues without subsequent implant or flap reconstruction
Prior history of explant surgery or implant removal due to infection or wound healing issues without subsequent implant or flap reconstruction
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Mayo Clinic · Scottsdale, Arizona
- California Protons Cancer Therapy Center · San Diego, California
- University of Florida Proton Therapy Institute · Jacksonville, Florida
- Miami Cancer Institute · Miami, Florida
- Emory Proton Therapy Center · Atlanta, Georgia
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
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