OncoMatch/Clinical Trials/NCT05848687
TINI 2: Total Therapy for Infants With Acute Lymphoblastic Leukemia II
Is NCT05848687 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies multiple treatments for lymphoblastic leukemia.
Treatment: Dexamethasone · Mitoxantrone · PEG asparaginase · Bortezomib · Vorinostat · Mercaptopurine · Methotrexate · Blinatumomab · Ziftomenib — The purpose of this study is to improve upon the TINI study treatment. The study will test the ability of a type of immunotherapy called blinatumomab to clear persistent leukemia. Blinatumomab targets CD19 which is located on the leukemia cells outer membrane.
Check if I qualifyExtracted eligibility criteria
Cancer type
Acute Lymphoblastic Leukemia
Biomarker criteria
Required: CD19 positive
Required: KMT2A (MLL) rearrangement
Prior therapy
Cannot have received: any prior therapy other than specified
Exception: hydroxyurea for 72 hours or less, systemic glucocorticoids for one week or less, cytarabine for 72 hours or less, one dose of vincristine, and one dose of intrathecal chemotherapy
Patients with prior therapy, other than therapy specified in inclusion criteria.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Phoenix Children's Hospital · Phoenix, Arizona
- Arkansas Children's Hospital · Little Rock, Arkansas
- Children's Hospital Los Angeles · Los Angeles, California
- Valley Children's Hospital · Madera, California
- Children's Hospital of Orange County · Orange, California
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
Could you qualify for this trial?
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