OncoMatch/Clinical Trials/NCT05805098
Venetoclax Combined With Homoharringtonine and Cytarabine in Induction for AML
Is NCT05805098 recruiting? Yes, currently enrolling (May 2026). This Phase 2/3 trial studies multiple treatments including Venetoclax and Homoharringtonine for acute myeloid leukemia.
Treatment: Venetoclax · Homoharringtonine · Cytarabine — This study aims to evaluate the efficacy and safety of venetoclax combined with homoharringtonine and cytarabine in the treatment of newly diagnosed acute myeloid leukemia.
Check if I qualifyExtracted eligibility criteria
Cancer type
Acute Myeloid Leukemia
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Lab requirements
Blood counts
White blood cell (WBC) count < 25 × 10^9 /L (hydroxyurea is permitted to meet this criterion)
Kidney function
Creatinine clearance ≥ 45 mL/min calculated by the Cockcroft Gault formula or measured by 24-hour urine collection; Creatinine clearance < 45 mL/min [excluded]
Liver function
Serum aspartate aminotransferase (AST) ≤ 3.0 × ULN, Serum alanine aminotransferase (ALT) ≤ 3.0 × ULN (unless considered due to leukemic organ involvement), Total bilirubin ≤ 1.5 × ULN, Moderate hepatic impairment with total bilirubin > 1.5 × ULN [excluded]
Cardiac function
Cardiac history of congestive heart failure requiring treatment or ejection fraction ≤ 50% or chronic stable angina [excluded]
Cardiac history of congestive heart failure requiring treatment or ejection fraction ≤ 50% or chronic stable angina. Diffusing capacity of the lung for carbon monoxide (DLCO) ≤ 65% or forced expiratory volume during the first second (FEV1) ≤ 65%. Creatinine clearance < 45 mL/min. Moderate hepatic impairment with total bilirubin > 1.5 × ULN. Laboratory values: Creatinine clearance ≥ 45 mL/min, AST ≤ 3.0 × ULN, ALT ≤ 3.0 × ULN (unless considered due to leukemic organ involvement), Total bilirubin ≤ 1.5 × ULN, WBC count < 25 × 10^9 /L (hydroxyurea is permitted to meet this criterion)
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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