OncoMatch/Clinical Trials/NCT05797168
Phase I/IIa Study of AZD5335 as Monotherapy and Combination Therapy in Participants With Solid Tumors
Is NCT05797168 recruiting? Yes, currently enrolling (Sep 2026). This Phase 1/2 trial studies multiple treatments for ovarian cancer.
Treatment: Torvutatug samrotecan · Saruparib · Bevacizumab · Carboplatin · Palacaparib · Pembrolizumab — This research is designed to determine if experimental treatment with Antibody-drug conjugate, AZD5335, alone, or in combination with anti-cancer agents is safe, tolerable, and has anti-cancer activity in patients with advanced tumors
Check if I qualifyExtracted eligibility criteria
Treatments studied
Immunotherapy
Targeted therapy
Chemotherapy
Other
Cancer type
Ovarian Cancer
Non-Small Cell Lung Carcinoma
Endometrial Cancer
Performance status
ECOG 0–1(Restricted strenuous activity)
Demographics
Prior therapy
Must have received: adequate prior therapy for tumor type and stage
Participants with advanced solid tumors must have received prior adequate therapy in accordance with local practice for their tumor type and stage of disease, or, in the opinion of the Investigator, a clinical trial is the best option for the next treatment based on response and/or tolerability to prior therapy.
Lab requirements
Blood counts
Kidney function
Liver function
Adequate organ and marrow function
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Research Site · Duarte, California
- Research Site · Irvine, California
- Research Site · La Jolla, California
- Research Site · Aurora, Colorado
- Research Site · Louisville, Kentucky
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT05797168 currently recruiting?
Yes, this trial is currently recruiting patients.
Is prior treatment required for enrollment?
Yes. Patients must have previously received adequate prior therapy for tumor type and stage.
Is there an age limit?
Yes. Patients must be 130 years or younger.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualify