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OncoMatch/Clinical Trials/NCT05772390

Partial Breast Re-irradiation in Women in Women with Locally Recurrent Breast Cancer Previously Treated with Conservative Surgery and Whole Breast Irradiation

Is NCT05772390 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies non-drug interventions for breast cancer.

Phase 2RecruitingIstituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCSNCT05772390Data as of May 2026

A prospective study of partial breast re-irradiation in patients with local recurrence of breast cancer

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Extracted eligibility criteria

Cancer type

Breast Carcinoma

Biomarker criteria

Excluded: BRCA1 pathogenic mutation

Excluded: BRCA2 pathogenic mutation

Excluded: TP53 pathogenic mutation

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

Must have received: breast conserving therapy (surgery and whole breast radiotherapy)

≥ 24 months interval between initial breast conserving therapy (surgery and whole breast radiotherapy) and recurrence

Cannot have received: IORT, brachytherapy or previous partial breast treatment

Previous breast RT performed with IORT, brachytherapy or previous partial breast treatment

Cannot have received: chemotherapy

Exception: within 2 weeks prior to study RT

Patients who had chemotherapy within 2 weeks prior to study RT

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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