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OncoMatch/Clinical Trials/NCT05759923

First-in-human Phase I Study to Evaluate Safety, Tolerability and Antineoplastic Activity of OATD-02 in Patients with Selected Advanced And/or Metastatic Solid Tumours

Is NCT05759923 recruiting? Yes, currently enrolling (Jun 2026). This Phase 1 trial studies OATD-02 for advanced ovarian carcinoma.

Phase 1RecruitingMolecure S.A.NCT05759923Data as of Jun 2026Location: Poland

Treatment: OATD-02The goal of this clinical trial is to learn if the OATD-02 administration (orally) in monotherapy is safe and has the pharmacodynamic potential to restore and enhance tumour responses to immunotherapy through increased arginine levels or intrinsic anti-tumour activity in participants with advanced metastatic colorectal cancer, ovarian cancer, renal cancer or pancreatic cancer.

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Extracted eligibility criteria

Treatments studied

Other

OATD-02

Cancer type

Ovarian Cancer

Renal Cell Carcinoma

Pancreatic Cancer

Colorectal Cancer

Disease stage

Required: Stage IV

Metastatic disease required

advanced and/or metastatic colorectal cancer, renal cell cancer, or pancreatic cancer or recurrent serous ovarian cancer

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

Min 1 prior line

Structured fields extracted by AI. May contain errors — verify against the official protocol.

Frequently asked questions

Is NCT05759923 currently recruiting?

Yes, this trial is currently recruiting patients.

What disease stage is eligible?

Stage IV is required (metastatic disease required).

Could you qualify for this trial?

Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.

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