OncoMatch/Clinical Trials/NCT05738694
Neoadjuvant of Axitinib Plus PD-1 to Improve Disease Free Survival of Patients With Renal Cell Carcinoma
Is NCT05738694 recruiting? Yes, currently enrolling (Jun 2026). This Phase 3 trial studies Axitinib plus Toripalimab for renal cell carcinoma.
Treatment: Axitinib plus Toripalimab — The study included 298 RCC patients who were at high risk for recurrence after nephrectomy (T2G3-4 or T3-4 or N1). They were randomly divided to receive axitinib plus PD-1 + surgery or surgery alone at a ratio of 1:1, so as to determine the efficacy of the neoadjuvant combination of axitinib plus PD-1.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Renal Cell Carcinoma
Disease stage
Required: Stage T2G4, T2 WITH SARCOMATOID DIFFERENTIATION
Grade: G4
CT or MRI clinical staging is T2G4 or T2 with sarcomatoid differentiation, T3-4, N1
Performance status
ECOG 0–1(Restricted strenuous activity)
Demographics
Lab requirements
Blood counts
WBC≥3.5×10^9/L, absolute neutrophil count ≥1.5×10^9/L, PLT≥75.0×10^9/L, HGB≥80g/L
Kidney function
GFR ≥ 45 ml/min
Liver function
Total bilirubin ≤1.5×ULN, AST and ALT ≤2.5×ULN
Cardiac function
Cardiac function class 0-2
Sufficient heart, bone marrow, liver, and kidney functions: Cardiac function: Cardiac function class 0-2; Blood routine test: WBC≥3.5×10^9/L, absolute neutrophil count ≥1.5×10^9/L, PLT≥75.0×10^9/L, HGB≥80g/L; Liver function: Total bilirubin ≤1.5×ULN, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5×ULN; Renal function: GFR ≥ 45 ml/min.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT05738694 currently recruiting?
Yes, this trial is currently recruiting patients.
What disease stage is eligible?
Stage T2G4 or T2 WITH SARCOMATOID DIFFERENTIATION is required.
Is there an age limit?
Yes. Patients must be 80 years or younger.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages