OncoMatch/Clinical Trials/NCT05737303

Nab-paclitaxel Versus Sb-taxanes As First-Line Treatment in Advanced Ovarian Cancer

Is NCT05737303 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies nab-paclitaxel combined with carboplatin for epithelial ovarian carcinoma stage iii.

Phase 3RecruitingWomen's Hospital School Of Medicine Zhejiang UniversityNCT05737303Data as of May 2026

Treatment: nab-paclitaxel combined with carboplatin — The purpose of this study is to compare the efficacy and safety of nab-paclitaxel with solvent-based taxanes as first-line treatment for patients with advanced primary epithelial ovarian cancer (EOC), primary peritoneal carcinoma or fallopian tube carcinoma.

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Extracted eligibility criteria

Cancer type

Ovarian Cancer

Disease stage

Required: Stage III, IV

Performance status

ECOG 0–2(Ambulatory, capable of self-care)

Prior therapy

No prior treatment (treatment-naive required)

Max 0 prior lines

Cannot have received: chemotherapy

Cannot have received: radiation therapy

Lab requirements

Blood counts

severe myelosuppression excluded

Kidney function

renal dysfunction at the time of screening excluded

Liver function

severe liver dysfunction (Child's Class III) excluded

Cardiac function

Grade Ⅱ or above myocardial ischemia or myocardial infarction, poorly controlled arrhythmias (including QTc interval ≥470 ms); NYHA grade Ⅲ to Ⅳ cardiac insufficiency or LVEF < 55% indicated by color Doppler ultrasonography excluded

Patients with severe myelosuppression, severe liver dysfunction (Child's Class III), or renal dysfunction at the time of screening; Severe cardiovascular disease: Grade Ⅱ or above myocardial ischemia or myocardial infarction, poorly controlled arrhythmias (including QTc interval ≥470 ms); According to NYHA（New York Heart Association） criteria, patients with grade Ⅲ to Ⅳ cardiac insufficiency or left ventricular ejection fraction (LVEF) < 55% indicated by color Doppler ultrasonography

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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