OncoMatch/Clinical Trials/NCT05735145
Concurrent Chemoradiotherapy Combined With Adjuvant Chemotherapy Treated Advanced Cervical Cancer
Is NCT05735145 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies paclitaxel combined with platinum for uterine cervical neoplasms.
Treatment: paclitaxel combined with platinum — This study carried out a prospective, randomized, controlled clinical study under the background of intensity-modulated radiation therapy and three-dimensional afterloading therapy. By comparing simultaneous intensity-modulated radiotherapy and chemotherapy combined with adjuvant chemotherapy and simultaneous intensity-modulated radiotherapy and chemotherapy alone, based on the 2018 FIGO staging The clinical efficacy of locally advanced cervical cancer further clarifies the role of adjuvant chemotherapy in locally advanced cervical cancer.
Check if I qualifyExtracted eligibility criteria
Cancer type
Cervical Cancer
Disease stage
Required: Stage IIB, IIIA, IIIB, IVA (FIGO 2018)
FIGO stage IB3, IIA2, IIB-IVA patients in 2018
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: concurrent intensity-modulated chemoradiotherapy followed by three-dimensional afterloading treatment — after diagnosis
Locally advanced cervical cancer patients received standard concurrent intensity-modulated chemoradiotherapy followed by three-dimensional afterloading treatment after diagnosis, and the effect reached CR after treatment
Cannot have received: neoadjuvant chemotherapy and surgery
Patients who have received neoadjuvant chemotherapy and surgery
Lab requirements
Blood counts
serum hemoglobin >=100*10^9/l, blood platelet >= 100000/μl, absolute count of neutrophils>=1500/μl
Kidney function
serum creatinine <=1.5 unl or creatinine clearance >= 60 ml/min
Liver function
serum bilirubin <=1.5 unl, ast (sgot) and alt (sgpt)<= 1.5 unl
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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