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OncoMatch/Clinical Trials/NCT05711667

A Study of the Drug Letermovir as Prevention of Cytomegalovirus Infection After Stem Cell Transplant in Pediatric Patients

Is NCT05711667 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies Letermovir for hematopoietic and lymphoid cell neoplasm.

Phase 3RecruitingChildren's Oncology GroupNCT05711667Data as of May 2026

Treatment: Letermovir — This phase III single arm trial determines whether taking prophylactic letermovir will reduce the likelihood of infection with cytomegalovirus (CMV) in children and adolescents after stem cell transplant compared to estimated rate of infection without prophylaxis. The treatments used to prepare for HCT reduce the body's natural infection-fighting ability and increase the likelihood of an infection with a virus called cytomegalovirus. "Prophylaxis" means to take a drug to prevent a disease or side effect. Letermovir is an antiviral drug that stops cytomegalovirus from multiplying and may prevent cytomegalovirus infection and make the disease less severe.

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Extracted eligibility criteria

Cancer type

Acute Myeloid Leukemia

Acute Lymphoblastic Leukemia

Non-Hodgkin Lymphoma

Multiple Myeloma

Myelodysplastic Syndrome

Chronic Lymphocytic Leukemia

Tumor Agnostic

Prior therapy

Cannot have received: allogeneic hematopoietic cell transplant

Receipt of prior allogeneic HCT within one year of study enrollment

Lab requirements

Kidney function

Estimated glomerular filtration rate > 10 mL/min/1.73 m^2 and not receiving dialysis

Liver function

Direct bilirubin <= 2 mg/dL and serum glutamate-pyruvate transaminase (SGPT/ALT) <= 10 x ULN for age (ULN for SGPT/ALT set to 45 U/L)

Estimated glomerular filtration rate > 10 mL/min/1.73 m^2 and not receiving dialysis; Direct bilirubin <= 2 mg/dL and serum glutamate-pyruvate transaminase (SGPT/ALT) <= 10 x ULN for age

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Children's Hospital of Alabama · Birmingham, Alabama
  • UCSF Benioff Children's Hospital Oakland · Oakland, California
  • UCSF Medical Center-Mission Bay · San Francisco, California
  • Children's Hospital Colorado · Aurora, Colorado
  • Alfred I duPont Hospital for Children · Wilmington, Delaware

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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