OncoMatch/Clinical Trials/NCT05702398
Pilot Trial of Supplemental Vitamin A and Nicotinamide
Is NCT05702398 recruiting? Yes, currently enrolling (Jun 2026). This Early Phase 1 trial studies multiple treatments including Vitamin A and Nicotinamide for skin cancer.
Treatment: Vitamin A · Nicotinamide — The goal of this clinical trial is to assess the feasibility and safety of oral nicotinamide (NAM; a derivative of vitamin B3 \[niacin\]) and vitamin A in a high-risk population of kidney transplant recipients with a history of skin cancer to generate preliminary data for future cancer prevention clinical trials.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Melanoma
Tumor Agnostic
Disease stage
Excluded: Stage IV
Metastatic SCC or invasive melanoma within the past 5 years [excluded]
Prior therapy
Cannot have received: oral retinoid (acitretin)
Use of acitretin or other oral retinoids within the past 6 months
Cannot have received: supplement (nicotinamide, niacin, vitamin A, beta carotene)
Use of supplemental NAM, niacin, vitamin A, or beta carotene within the past 6 months
Cannot have received: field treatment for actinic keratoses
Field treatment for actinic keratoses (AKs) within the previous 4 weeks
Cannot have received: topical steroid
Use of topical steroids
Lab requirements
Kidney function
Renal impairment with eGFR<15 mL/min/1.73 m2 [excluded]
Liver function
Liver disease [excluded]
Cardiac function
Recent myocardial infarction [excluded]; Hypotension [excluded]
Liver disease; Renal impairment with eGFR<15 mL/min/1.73 m2; Recent myocardial infarction; Hypotension
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Rhode Island Hospital · Providence, Rhode Island
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT05702398 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior oral retinoid, supplement, field treatment for actinic keratoses disqualifies patients from enrollment.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages