OncoMatch/Clinical Trials/NCT05686798
Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.
Is NCT05686798 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies Ad5-yCD/mutTKSR39rep-ADP adenovirus and fractionated stereotactic radiosurgery (fSRS) for malignant glioma of brain.
Treatment: Ad5-yCD/mutTKSR39rep-ADP adenovirus and fractionated stereotactic radiosurgery (fSRS) — The primary goal of this Phase I study is to determine the maximum tolerated dose of oncolytic adenovirus mediated double suicide-gene therapy in combination with fractionated stereotactic radiosurgery in patients with recurrent high-grade astrocytoma undergoing resection.
Check if I qualifyExtracted eligibility criteria
Cancer type
Glioblastoma
Disease stage
Grade: high-grade
radiologic evidence of intracranial recurrence or progression of a previously diagnosed high-grade astrocytoma
Prior therapy
Must have received: radiation therapy
An interval of at least 3 months must have elapsed since the completion of the most recent course of radiation
Cannot have received: gene or virus therapy
No prior treatment of the tumor with gene or virus therapy
Cannot have received: immunotherapy
No prior treatment of the tumor with...immunotherapy
Cannot have received: brachytherapy
No prior treatment of the tumor with...brachytherapy
Cannot have received: polymer implant containing chemotherapeutic agents (Gliadel Wafer)
No prior treatment of the tumor with...implants of polymers containing chemotherapeutic agents (e.g. Gliadel Wafer)
Lab requirements
Blood counts
platelet count ≥ 100,000/μl; absolute neutrophil count ≥ 1,000/μl; hemoglobin > 10.0 g/dl
Kidney function
creatinine clearance ≥ 50 ml/min/m2
Liver function
bilirubin < 1.5 mg/dl; sgot and sgpt < 2.5 times upper limit of normal (uln)
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Henry Ford Health System · Detroit, Michigan
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualify