OncoMatch/Clinical Trials/NCT05684276
DUMAS: Neo-Adjuvant Immunotherapy for Pancoast Tumors
Is NCT05684276 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Carboplatin and Paclitaxel for nsclc.
Treatment: Carboplatin · Paclitaxel · Nivolumab — The goal of this clinical trial is to test the efficacy of induction treatment of immunotherapy and chemotherapy depending on the resection status for the treatment of non small cell lung cancer patients diagnosed with pancoast tumor. The main objectives it aims to answer are: * Complete resection rate after induction treatment with chemotherapy plus nivolumab * Overall Survival and Progression Free Survival at 24 months The sample size is 40 patients.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Small Cell Lung Carcinoma
Biomarker criteria
Excluded: EGFR activating mutation in the TK domain
activating mutations in the TK domain of EGFR
Excluded: ALK any variety of alterations
any variety of alterations in the ALK gene
Excluded: ROS1 mutation
ROS1 mutations
Disease stage
Required: Stage IIB, IIIA, T3N2 (IIIB) (8th edition of the TNM)
stages IIB, IIIA and T3N2 (IIIB) patients
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: antineoplastic drugs
previous treatment with antineoplastic drugs
Cannot have received: chest radiotherapy
previous treatment with chest radiotherapy
Cannot have received: surgery for lung cancer or for another reason
previous surgery for lung cancer or for another reason
Cannot have received: anti-PD-1 therapy
prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA-4 antibody, or any other antibody or drug specifically targeting T-cell co-stimulation or immune checkpoint pathways
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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