OncoMatch/Clinical Trials/NCT05675813
Genotype-guided Treatment in Newly Diagnosed PTCL
Is NCT05675813 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies multiple treatments including CHOP+selinexor+5-Azacitidine and CHOP+duvelisib+5-Azacitidine for peripheral t cell lymphoma.
Treatment: CHOP+selinexor+5-Azacitidine · CHOP+duvelisib+5-Azacitidine · CHOP+chidamide+tislelizumab · standard CHOP — This study includes Phase I and Phase II stages. Phase I is an open-label trial to confirm RP2D of oral targeted agents in three genetic subtypes. Phase II is a multicenter, prospective, randomized, open-label, controlled trial to evaluate the efficacy and safety of genotype-guided targeted agents plus cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP-X2) versus cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) in patients with peripheral T-cell lymphoma.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Hodgkin Lymphoma
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Lab requirements
Blood counts
Neutrophils ≥ 1.0×10^9/L; Platelets ≥ 75×10^9/L (≥ 50×10^9/L if bone marrow involvement)
Kidney function
Creatinine ≤ 1.5x ULN
Liver function
ALT or AST ≤ 2.5x ULN; AKP and bilirubin ≤ 1.5x ULN
Neutrophils<1.0×10^9/L Platelets<75×10^9/L (Platelets<50×10^9/L in case of bone marrow involvement) ALT or AST is 2.5 times higher than the upper limits of normal (ULN), AKP and bilirubin are 1.5 times higher than the ULN. Creatinine is 1.5 times higher than the ULN.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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