OncoMatch/Clinical Trials/NCT05674175
Co-administration of CART22-65s and huCART19 for B-ALL
Is NCT05674175 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies multiple treatments including Autologous, humanized anti-CD22 CAR T cell therapy (CART22-65s) and Autologous, humanized anti-CD19 CAR T cell therapy (huCART19) for b-cell acute lymphoblastic leukemia.
Treatment: Autologous, humanized anti-CD22 CAR T cell therapy (CART22-65s) · Autologous, humanized anti-CD19 CAR T cell therapy (huCART19) — This study will evaluate the safety and efficacy of administering two CAR T cell products, huCART19 and CART22-65s, in children with advanced B cell Acute Lymphoblastic Leukemia (B-ALL).
Check if I qualifyExtracted eligibility criteria
Cancer type
Acute Lymphoblastic Leukemia
Non-Hodgkin Lymphoma
Biomarker criteria
Required: CD19 expression (positive)
Required: CD22 expression (positive)
Lab requirements
Blood counts
Adequate organ function
Kidney function
Adequate organ function
Liver function
Adequate organ function
Adequate organ function
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Children's Hospital of Philadelphia · Philadelphia, Pennsylvania
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