OncoMatch/Clinical Trials/NCT05650749
GPC2 CAR T Cells for Relapsed or Refractory Neuroblastoma and Metastatic Retinoblastoma
Is NCT05650749 recruiting? Yes, currently enrolling (Jun 2026). This Phase 1 trial studies GPC2 CAR T cells for refractory neuroblastoma.
Treatment: GPC2 CAR T cells — This is a first in human dose escalation trial to determine the safety of administering GPC2 CAR T cells in patients with advanced neuroblastoma or retinoblastoma.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Neuroblastoma
Disease stage
Required: Stage HIGH-RISK (COG), STAGE IVA, STAGE IVB (COG (Neuroblastoma), IRSS (Retinoblastoma))
Excluded: Stage STAGE III (RETINOBLASTOMA COHORT 1)
Metastatic disease required
high-risk neuroblastoma according to COG risk classification; metastatic retinoblastoma according to IRSS
Demographics
Lab requirements
Kidney function
age-adjusted serum creatinine ≤1.5 ULN for age
Liver function
Total bilirubin ≤ 1.5 x ULN (exception: ≤ 3 ULN for Gilbert's Disease); AST/ALT ≤ 2.5 ULN (≤ 5 x ULN with liver metastases)
Cardiac function
LVSF ≥28% or LVEF ≥ 50% confirmed by Echo, or adequate ventricular function documented by a scan or a cardiologist
Total bilirubin ≤ 1.5 x ULN (exception: ≤ 3 ULN for Gilbert's Disease); AST/ALT ≤ 2.5 ULN (≤ 5 x ULN with liver metastases); age-adjusted serum creatinine ≤1.5 ULN for age; LVSF ≥28% or LVEF ≥ 50% confirmed by Echo, or adequate ventricular function documented by a scan or a cardiologist
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Children's Hospital of Philadelphia · Philadelphia, Pennsylvania
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT05650749 currently recruiting?
Yes, this trial is currently recruiting patients.
What disease stage is eligible?
Stage HIGH-RISK (COG) or STAGE IVA or STAGE IVB is required (metastatic disease required).
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages